Employing Novel Types of Nanocarriers

	Phenolsulfonephtalein inhibits amyloid fibril formation

The improvement of drug delivery by employing novel types of nanocarriers constitutes one of the central goals of nanomedicine. A possible approach to supply drugs linked to nanocarriers on demand, is the disposal of semi-implantable drug delivery systems.

 

Taking into consideration the priorities of research in the area of drug delivery in the field of nanomedicine, it has been decided to focus on applications in two specific clinical topics:

• Diabetes: Developing a semi-implantable device which will carry out detection of glucose level in blood coupled with the delivery of insulin, coupled with nanocarriers. Within the scope of the preferred strategy an array of microneedles are incorporated, that penetrate the stratum corneum impermeable layer of skin (Project leader: Dr. Michael Loughran, Tyndall National Institute).
• Cancer: Developing implantable or semi-implantable device for local electric stimulation on the side of the primary tumor following a local injection of nano-carriers linked to chemotherapeutic agents (Project leader: Prof. Rafi Korenstein, Tel-Aviv University).

Required collaboration:

• Diabetes: Researchers engaged in fabrication and characterization of microneedle arrays; researchers studying novel approaches for a quantitative and repeatable detection of glucose.
• Cancer: Researchers who are engaged in production and employment of chemotherapeutic agents linked to nanocarriers in cancer treatment.